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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Pain. 2017 Dec;158(12):2431–2441. doi: 10.1097/j.pain.0000000000001050

Figure 2. MMG22-Induced Reversal of Tactile Hypersensitivity in Neuropathic Pain.

Figure 2

Spared nerve injury surgery was performed to induce tactile hypersensitivity. vF thresholds were measured on days 3, 7, 17, and dose-response curves to intrathecal MMG22 were constructed. (A) Dose-response curves to MMG22 (1, 100, 1000 pmol) were constructed on days 3, 7, and 17 post-surgery, n = 3–4 per dose group (B-D). The duration of action of each dose of MMG22 is shown at 5, 12, and 20 minutes post-injection of MMG22 on days 3 (B), 7 (C) and 17 (D), and 28 (E) post-injury. A saline-treated group was included as control. *Signifies significant differences of the 300 and 1000 pmol dose groups at the specified time points. p <0.05 one way ANOVA, Dunnett’s post-hoc test for comparisons to a control group (vehicle), n = 3–4 subjects per group for A-D, and 8 per group for E. (F) The duration of action of a higher dose range of MMG22 at 2, 4, and 6 hours post-injection of MMG22 on day 21 post-surgery. A saline-treated group was included as control. *Signifies significant differences of the 5000 and 10,000 pmol dose groups at the specified time points. p <0.05 one way ANOVA, Dunnett’s post-hoc test for comparisons to a control group (vehicle), n = 3–5 mice per group.