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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Pain. 2017 Dec;158(12):2431–2441. doi: 10.1097/j.pain.0000000000001050

Figure 5. The MMG22 monovalents M19 and MG20 do not interact.

Figure 5

Monovalent ligands were generated for oxymorphamine (M19) and MPEP (MG20). The mu opioid monovalent M19 dose-dependently reversed tactile hypersensitivity (black diamonds, ED50 value 1.1 nmol, 0.45–2.9). However, the MPEP based monovalent MG20 had no effect (white diamonds). When co-administered, MG20 had no effect on the potency of M19 (half-filled diamonds, ED50 value 0.9 nmol, 0.5–1.5). n = 7 mice per group.