Table 1.
Clinical Probabilities and ranges of values for each variable used in the decision model.
| Variable | Base-case | Range | Reference(s) | |
|---|---|---|---|---|
| Low | High | |||
|
| ||||
| Age, y | 76 | 40 | 90 | 12,17,18 |
|
| ||||
| Annual ED Visits | 30,000 | 10,000 | 100,000 | Estimate |
|
| ||||
| Percentage of ED Patients with Suspected Sepsis | 17.8% | 10% | 25% | 21 |
|
| ||||
| Percentage of ED Patients with Severe Sepsis | 0.7% | 0 | 2% | 1 |
|
| ||||
| Percentage of Severe Sepsis Patients with Elevated Lactates ≥ 4 mmol/L | 21% | 6% | 36% | 3,12,22 |
|
| ||||
| Patients with Adequate Lactate Clearance (%) | 68% | 46% | 90% | 8–10,23 |
|
| ||||
| Absolute In-Hospital Mortality Reduction due to POC Lactate Program | 2% | 0% | 10% | Estimate |
|
| ||||
| In-Hospital Mortality Among Patients with Adequate Lactate Clearance (%) | 19.2% | 5% | 40% | 8–10,23 |
|
| ||||
| In-Hospital Mortality Among Patients with Inadequate Lactate Clearance (%) | 61.4% | 50% | 80% | 8–10,23 |