Table 5.
One-way sensitivity results for POC Lactate Program compared with Usual Care Strategy with a willingness-to-pay threshold of $50,000/QALY.
| Variable | Usual Care Strategy Preferred | POC Lactate Preferred | ||
|---|---|---|---|---|
| Cost-Effective Range of POC Lactate Program | Dominance Range of POC Lactate Program | |||
|
| ||||
| Percentage of Severe Sepsis Patients who have Lactate ≥ 4mmol/L (%) | < 17.2% | 17.2%–36.0% | > 36% | |
|
| ||||
| Percentage of ED patients who have Severe Sepsis (%) | < 0.6% | 0.6%–1.2% | > 1.2% | |
|
| ||||
| Number of Annual ED Visits | < 25,000 | 25,000 – 51,000 | > 51,000 | |
|
| ||||
| In-Hospital Mortality Reduction from POC Lactate Program | < 1.4% | 1.4% – 10% | - | |
|
| ||||
| Fixed Costs POC of Lactate Program (one time cost) | > $42,000 | $21,000 – $42,000 | < $21,000 | |
|
| ||||
| Variable Costs of POC Lactate Program (cost of lactate measurement for individual patient) | > $16 | $8-$16 | - | |
|
| ||||
| Mean patent age among ED patients with suspected sepsis | > 84 yo | 40 – 84 yo | - | |
|
| ||||
| Percentage of ED Patients with Severe Sepsis who have adequate Lactate Clearance for floor admission (%) | < 40% | 40–90% | - | |
|
| ||||
| Cost of Admission to ICU with Survival | < $33,000 | $33,000 – $60,000 | - | |