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. 2016 Oct 22;139(12):3202–3216. doi: 10.1093/brain/aww250

Figure 2.

Figure 2

Abundant dipeptide repeat protein inclusions in the near absence of TDP-43 aggregation (Case 1). (A) Representative images show dipeptide repeat protein inclusions in degenerate and non-degenerate brain regions. pTDP-43 immunostaining showed sparse to absent TDP-43 inclusions. GA, GP and GR NCI were abundant whereas PA and PR aggregates were sparse to absent. Scale bars = 25 µm. (B) Occasional neuronal intranuclear inclusions (NII) were also observed, often adjacent to the nucleolus, for all dipeptide repeat proteins except for PA. Scale bar = 10 µm. sACC = subgenual anterior cingulate cortex; Calc ctx = calcarine cortex; Hip-DG = dentate gyrus of hippocampus.