Table 1.
Sham condition Mean ± SD | SWA disruption Mean ± SD | P-value | |
---|---|---|---|
Demographics | |||
Age (years) | 54.1 ± 6.7 | n/a | |
Race White n (%) | 11 (65) | n/a | |
Sex female n (%) | 11 (65) | n/a | |
Body mass index (kg/m2) | 28.2 ± 4.3 | n/a | |
Education (years) | 15.8 ± 1.6 | n/a | |
Alcohol (drinks/week) | 1.6 ± 2.1 | n/a | |
MMSE | 29.6 ± 0.5 | n/a | |
APOE ɛ4 carrier n (%) | 5 (29) | n/a | |
Polysomnogram | |||
Total sleep time (min) | 419 ± 47 | 404 ± 51 | 0.160 |
non-REM sleep (min) | 311 ± 39 | 300 ± 49 | 0.244 |
N1 (min) | 22 ± 10 | 34 ± 18 | 0.007 |
N2 (min) | 265 ± 44 | 254 ± 43 | 0.33 |
N3 (min) | 7 ± 42a | 0 ± 2a | <0.001a |
REM (min) | 99 ± 52a | 68 ± 38a | 0.001a |
Sleep efficiency (%) | 85.4 ± 8.5 | 82.4 ± 9.6 | 0.102 |
Number tones delivered | 0 | 1177 ± 427 | n/a |
EEG spectral power | |||
0.5–4 Hz (Delta) (μV2×s) | 118 ± 51 | 96 ± 43 | <0.001 |
4–8 Hz (μV2×s) | 12.8 ± 5.4 | 12.0 ± 5.4 | 0.215 |
8–12 Hz (μV2×s) | 6.2 ± 3.0 | 6.4 ± 3.7 | 0.535 |
12–18 Hz (μV2×s) | 2.7 ± 1.2 | 3.0 ± 1.3 | 0.005 |
18–32 Hz (μV2×s) | 1.7 ± 0.8 | 2.1 ± 0.9 | 0.008 |
Actigraphy (n = 14) | |||
Total sleep time (min), mean six nights | 377 ± 56 | 370 ± 43 | 0.445 |
Total sleep time (min), polysomnogram night | 422 ± 42 | 404 ± 41 | 0.117 |
Sleep efficiency (%), mean six nights | 82.6 ± 7.5 | 82.0 ± 6.7 | 0.655 |
Time in bed (min)b | 456 ± 46 | 454 ± 37 | 0.836 |
Mid-sleep (hh:min)b | 03:48 am ± 00:23 | 03:47 am ± 00:19 | 0.836 |
Questionnaires | |||
Pittsburgh Sleep Quality Indexc | 4.2 ± 1.6 | 3.4 ± 1.8 | 0.059 |
Epworth Sleepiness Scalec | 5.6 ± 3.6 | 6.4 ± 3.4 | 0.133 |
Awakened by noise? (yes)d | 1/16 | 12/15 | <0.001 |
Number tones heard?d | 3 (n = 1) | 11.1 ± 8.9 | n/a |
Estimated sleep hours | 7.3 ± 1.1 | 5.2 ± 2 | <0.001 |
Estimated sleep quality | 7.4 ± 1.7 | 5.5 ± 2.7 | 0.02 |
Stanford Sleepiness Scale | 2.0 ± 0.9 | 2.8 ± 1.8 | 0.16 |
aMedian ± interquartile range; P-value is for related-samples Wilcoxon signed rank test.
bn = 17.
cCompleted during daytime 5–14 days prior to polysomnogram nights.
dNot all participants answered this question.