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. 2017 Dec 28;13(12):e1006749. doi: 10.1371/journal.ppat.1006749

Fig 6. Structural mapping of major Yamagata-lineage ‘clade-defining’ trunk substitutions on influenza B virus polymerase complex.

Fig 6

(A) Crystal structure of influenza B virus polymerase (PDB: 5MSG) bound to template vRNA shown in cartoon view colored by subunit, highlighting locations of residues of interest as spheres colored by presence of change in Yamagata-lineage clade 2 (orange) or clade 3 (red) viruses. Zoomed-in view of substitutions (B, C) at PB1-PA interface fixed in clade 2 viruses and (D, E) at PB1-vRNA interface fixed in clade 3 viruses.