Table 1.
Effects of Glial Modulators in Preclinical Behavioral Studies
| Drug of abuse | Behavior | Intervention | Effect | Citation |
|---|---|---|---|---|
| Opioids | Conditioned Place Preference | Microglial inhibitor | ↓ | Hutchinson et al., 2008 |
| TLR4 antagonist | ↓ | Hutchinson et al., 2012 | ||
| GLT-1 upregulation/activation | ↓ | Fujio et al., 2005; Nakagawa et al., 2005 | ||
| Self-administration | TLR4 antagonist | ↓ | Hutchinson et al., 2012 | |
| PPARγ agonist | ↓ | de Guglielmo et al., 2015 | ||
| Drug Seeking | Microglial inhibitor | ↓ | Arezoomandan and Haghparast, 2016 | |
| TLR4 antagonist | ↓ | Theberge et al., 2013 | ||
| PPARγ agonist | ↓ | de Guglielmo et al., 2016, 2015 | ||
| GLT-1 upregulation/activation | ↓ | Shen et al., 2014 | ||
| Cystine-glutamate exchange activator | ↓ | Zhou and Kalivas, 2008 | ||
| Alcohol | Drinking/Self-administration | Microglial inhibitor | ↓ | Agrawal et al., 2011; Bell et al., 2013; Syapin et al., 2016 |
| TLR4 antagonist | NC | Harris et al., 2016 | ||
| PPARγ agonist | ↓ | Blednov et al., 2015; Ferguson et al., 2014; Stopponi et al., 2013 | ||
| GLT-1 upregulation/activation | ↓ | Alhaddad et al., 2014; Das et al., 2015; Sari et al., 2016, 2011 | ||
| Astrocytic Gq DREADD activation | ↓ | Bull et al., 2014 | ||
| Drug Seeking | Microglial inhibitor | ↓ | Bell et al., 2013 | |
| GLT-1 upregulation/activation | ↓ | Qrunfleh et al., 2013; Rao and Sari, 2014; Weiland et al., 2015 | ||
| Psychostimulants | Conditioned Place Preference | Microglial inhibitor | ↓ | Northcutt et al., 2015; Poland et al., 2016 |
| TLR4 antagonist | ↓ | Northcutt et al., 2015 | ||
| GLT-1 upregulation/activation | NC | Abulseoud et al., 2012 | ||
| Self-administration | Microglial inhibitor | ↓ | Snider et al., 2013 | |
| TLR4 antagonist | ↓ | Northcutt et al., 2015; Tanda et al., 2016 | ||
| GLT-1 upregulation/activation | ↓ | Ward et al., 2011 | ||
| Cystine-glutamate exchange activator | NC | Murray et al., 2012 | ||
| Drug Seeking | Microglial inhibitor | ↓ | Beardsley et al., 2010 | |
| TLR4 antagonist | NC | Theberge et al., 2013 | ||
| PPARγ agonist | ↓ | Miller et al., 2016 | ||
| Astrocytic Gq DREADD activation | ↓ | Scofield et al., 2015 | ||
| GLT-1 upregulation/activation | ↓ | Abulseoud et al., 2012; Knackstedt et al., 2010; Sari et al., 2009 | ||
| Cystine-glutamate exchange activator | ↓ | Baker et al., 2003; Madayag et al., 2007; Murray et al., 2012; Reichel et al., 2011; Reissner et al., 2015 |
↓ - Significant decrease; NC - No significant change detected