Table 3.
Effect of high carb diet on LDL size and apoC-III proteoforms by LDL conversion groups
| Pattern A Low Carb (n=14) |
Pattern B High Carb (n=14) |
p-value | Pattern A Low Carb (n=20) |
Pattern A High Carb (n=20) |
p value |
|
|---|---|---|---|---|---|---|
| ApoC-III Total (ug/mL) |
72.55 (13.50) | 83.65 (18.18) | 0.004 | 81.1 (18.64) | 75.59 (15.84) | 0.11 |
| ApoC- III2 (ug/mL) |
9.32 (3.05) | 10.63 (4.54) | 0.04 | 11.72 (3.30) | 11.47 (3.65) | 0.96 |
| ApoC- III1 (ug/mL) |
38.47 (8.57) | 42.47 (10.91) | <.0001 | 40.01 (10.19) | 36.76 (8.66) | 0.17 |
| ApoC- III0a (ug/mL) |
4.63 (2.71) | 6.70 (3.29) | 0.004 | 6.23 (3.24) | 5.35 (3.06) | 0.44 |
| ApoC- III0b (ug/mL) |
13.88 (2.38) | 16.48 (3.42) | 0.008 | 15.41 (4.24) | 13.83 (4.26) | 0.26 |
| LDL Size (A0) |
266.007 (1.95) | 253.42 (5.30) | <.0001 | 269.37 (4.68) | 265.27 (3.87) | <.0001 |
| BMI (kg/m2) |
26.52 (3.09) | 26.47 (3.12) | 0.3 | 25.405 (2.87) | 25.17 (2.69) | 0.03 |
| TG (mg/dL) |
94.92 (37.66) | 143.07 (35.58) | 0.0007 | 100.25 (30.44) | 86 (23.90) | 0.126 |
| TC (mg/dL) |
169.21 (29.51) | 174.5 (30.88) | 0.07 | 184.7 (27.05) | 180.35 (30.99) | 0.778 |
| LDL-C. (mg/dL) |
110.92 (25.39) | 112.21 (27.33) | 0.147 | 119.5 (24.48) | 117.1 (28.56) | 0.05 |
| HDL-C (mg/dL) |
39.28 (6.25) | 33.57 (5.91) | <.0001 | 45.2 (9.00) | 46 (8.44) | 0.15 |
| ApoB (mg/dL) |
85.28 (18.54) | 98.21 (16.95) | <.0001 | 90.68 (13.96) | 86.65 (15.72) | 0.05 |
| ApoA-I (mg/dL) |
103.5 (12.20) | 100.5 (12.81) | 0.0012 | 114.94 (16.25) | 112.05 (13.70) | 0.13 |
Means (SD)
Groups pre and post were compared using a paired T-test
BMI: Body mass index. TG: Triglyceride. TC: Total cholesterol