Table 3. Clinical and metabolic variables associated with NASH by univariate and multivariate analysis.
| Variable | Unadjusted OR (95% CI) |
Adjusted OR (95% CI) |
p |
|---|---|---|---|
| Age (per 10 years) | 1.06 (0.71–1.59) | ||
| Male gender (yes vs. no) | 1.18 (0.37–3.74) | ||
| Black Ethnicity (yes vs. no) | 0.21 (0.04–0.78) | ||
| Diabetes (yes vs. no) | 2.76 (0.97–7.91) | ||
| BMI (per Kg/m2) | 1.04 (0.94–1.16) | ||
|
Time since HIV diagnosis (per 10 years) |
2.49 (1.34–4.62) | ||
| Detectable HIV viral load (>40 cp/mL) | 6.43 (1.34–30.94) | 4.44 (0.43–45.70) | 0.21 |
| AST (per 10 IU/L) | 4.31 (2.42–7.70) | ||
| ALT (per 10 IU/L) | 2.50 (1.73–3.62) | 2.39 (1.50–3.79) | <0.001 |
| GGT (per 10 IU/L) | 1.11 (1.01–1.21) | ||
| HOMA-IR (per unit) | 1.19 (1.04–1.37) | 1.20 (1.01–1.43) | 0.03 |
| HDL cholesterol (per mmol/L) | 0.04 (0.005–0.31) | ||
| Triglycerides (per mmol/L) | 1.41 (1.06–1.88) | ||
| LSM (per kPa) | 1.50 (1.26–1.77) |
p-value is considered significant when < 0.05. HOMA-IR was evaluated in 140 patients.
Abbreviations; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CI, confidence interval; GGT, gamma-glutamyl transpeptidase; HDL, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model for assessment of insulin resistance; LSM, liver stiffness measurement; OR, odds ratio; TE, transient elastography.