Table 1. Characteristics of the included studies.
| Study & year | Country | Ethnic | Histological type | Stage | Sample size | Detection method | Age (min-max) |
HER2 (positive/all) |
Follow up (months) |
Out-comes | HR (95%CI) |
Method for data collection | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Shang 2017 [9] |
China | Asian | Unclassified | NA | 136 | IHC | 54(21–83) median |
41/136 | 48 (all) |
OS | 1.81 (1.16–2.83) |
Directly | 7 |
| Wang 2016 [10] |
China | Asian | Unclassified | I-IV | 111 | IHC | 51.3(24–78) (mean) |
35/111 | NA | OS | 1.92 (1.12–3.26) |
Directly | 7 |
| Shandiz 2016 [11] |
Iran | Asian | Unclassified | I-IV | 47 | IHC | 51.6(19–71) (mean) |
12/47 | 27.7(6–60) (median) |
OS | 0.82 (0.66–1.02) | Indirectly | 7 |
| Shandiz 2016 [11] |
Iran | Asian | Unclassified | I-IV | 47 | IHC | 51.6(19–71) (mean) |
12/47 | 27.7(6–60) (median) |
DFS | 0.53 (0.04–7.57) |
Indirectly | 7 |
| Zhang 2015 [12] |
China | Asian | Unclassified | I-IV | 161 | IHC | NA | NA | 60 (all) |
OS | 3.46 (1.84–6.52) |
Directly | 8 |
| Despierre 2015 [13] |
Belgium | Caucasian | Unclassified | I-IV | 106 | FISH | 59(31–85) (median) |
53/106 | NA | OS | 0.97 (0.49–1.89) |
Directly | 8 |
| Despierre 2015 [13] |
Belgium | Caucasian | Unclassified | I-IV | 106 | FISH | 59(31–85) (median) |
53/106 | NA | PFS | 1.51 (0.87–2.63) |
Directly | 8 |
| Corkery 2015 [14] |
Canada | Caucasian | Serous | NA | 103 | IHC | NA | NA | NA | OS | 4.41 (1.95–9.95) |
Indirectly | 6 |
| Corkery 2015 [14] |
Canada | Caucasian | Serous | NA | 103 | IHC | NA | NA | NA | DFS | 1.54 (0.91–2.6) |
Indirectly | 6 |
| Demir 2014 [16] |
Sweden | Caucasian | Unclassified | I-IV | 82 | IHC | 54(24–80) (median) |
15/82 | NA | OS | 4.9 (2–12.04) |
Indirectly | 7 |
| Cai 2015 [6] |
China | Asian | Unclassified | I-IV | 95 | IHC | NA | 32/95 | NA | OS | 1.34 (0.77–2.32) |
Indirectly | 8 |
| Matsuo 2014 [15] |
USA | Mix | Serous | I-IV | 120 | IHC | 62.6±10.6 (mean) |
32/120 | NA | OS | 1.19 (0.67–2.11) |
Directly | 6 |
| Matsuo 2014 [15] |
USA | Mix | Serous | I-IV | 120 | IHC | 62.6±10.6 (mean) |
32/120 | NA | PFS | 1.04 (0.63–1.71) |
Directly | 6 |
| De Toledo 2013 [17] |
Brazil | Caucasian | Unclassified | I-IV | 152 | IHC | 55.2±12.3 (mean) |
19/152 | 43.6 (mean) |
OS | 1.46 (0.42–5.04) |
Directly | 7 |
| De Toledo 2013 [17] |
Brazil | Caucasian | Unclassified | I-IV | 152 | IHC | 55.2±12.3 (mean) |
19/152 | 43.6 (mean) |
DFS | 1.57 (0.39–6.22) |
Directly | 7 |
| Chay 2013 [18] |
Singapore | Mix | Serous | I-IV | 113 | IHC | 48.3(15.8–89) (median) | 31/113 | 2.8(0–19.99) (median) |
OS | 0.56 (0.21–1.52) |
Directly | 8 |
| Chay 2013 [18] |
Singapore | Mix | Serous | I-IV | 113 | IHC | 48.3(15.8–89) (median) | 31/113 | 2.8(0–19.99) (median) |
PFS | 0.5 (0.2–1.22) |
Directly | 8 |
| Steffensen 2011 [19] |
Denmark | Caucasian | Unclassified | I-IV | 139 | Elisa | 64(32–84) (median) |
NA | 39.6 (median) |
OS | 1.11 (0.68–1.79) |
Indirectly | 7 |
| Steffensen 2011 [19] |
Denmark | Caucasian | Unclassified | I-IV | 139 | Elisa | 64(32–84) (median) |
NA | 39.6 (median) |
PFS | 1.23 (0.64–2.39) |
Indirectly | 7 |
| Liu 2010 [20] |
China | Asian | Unclassified | I-IV | 116 | IHC | 49(30–76) (median) |
26/116 | 43(5–93) (median) |
OS | 2.83 (1.39–5.79) |
Indirectly | 9 |
| Liu 2010 [20] |
China | Asian | Unclassified | I-IV | 116 | IHC | 49(30–76) (median) |
26/116 | 43(5–93) (median) |
PFS | 1.92 (1–3.69) |
Indirectly | 9 |
| Pfisterer 2009 [21] |
Germany | Caucasian | Unclassified | IIB-IV | 359 | IHC | ≥18 | 22/359 | 57.5(46–64.3) (median) |
OS | 0.71 (0.42–1.18) |
Directly | 8 |
| Garcia-Velasco 2008 [23] |
Spain | Caucasian | Unclassified | NA | 72 | IHC | 57(28–82) (median) |
4/72 | 33 (median) |
OS | 2.28 (0.12–4.2) |
Directly | 7 |
| Garcia-Velasco 2009 [23] |
Spain | Caucasian | Unclassified | NA | 72 | IHC | 57(28–82) (median) |
4/72 | 33 (median) |
PFS | 2.82 (0.38–20.9) |
Directly | 7 |
| Graeff 2008 [24] |
Netherland | Caucasian | Unclassified | I-IV | 230 | IHC | 57.8(22–90) (median) |
12/230 | NA | OS | 1.02 (0.48–2.2) |
Directly | 6 |
| Graeff 2008 [24] |
Netherland | Caucasian | Unclassified | I-IV | 230 | IHC | 57.8(22–90) (median) |
12/230 | NA | PFS | 0.98 (0.46–2.1) |
Directly | 6 |
| Tomsova 2008 [22] |
Czech Republic | Caucasian | Unclassified | I-IV | 116 | IHC | 53(27–82) (median) |
10/116 | 39(1–120) (median) |
OS | 1.9 (0.79–4.58) |
Indirectly | 7 |
| Tuefferd 2007 [25] |
France | Caucasian | Unclassified | I-IV | 320 | IHC | 58(25–77) median |
41/320 | 24.9 (median) |
OS | 0.95 (0.51–1.74) |
Directly | 7 |
| Tuefferd 2007 [25] |
France | Caucasian | Unclassified | I-IV | 320 | IHC | 58(25–77) median |
41/320 | 24.9 (median) |
PFS | 0.81 (0.54–1.19) |
Directly | 7 |
| Steffensen 2007 [26] |
Denmark | Caucasian | Unclassified | II-IV | 160 | IHC | 54.5(29–70) median |
57/160 | 120 (all) |
OS | 1.5 (1.02–2.2) |
Directly | 8 |
| Pils 2007 [27] |
Austria | Caucasian | Unclassified | I-IV | 128 | IHC | 59.2 (mean) |
35/128 | 43.7(0.4–168.7) (median) |
OS | 1.92 (0.94–3.94) |
Indirectly | 7 |
| Malamou-Mitsi 2007[28] |
Greece | Caucasian | Unclassified | I-III | 95 | IHC | NA | 17/95 | 66(0.4–89.3) (median) |
OS | 1.85 (0.93–4.12) |
Indirectly | 7 |
| Malamou-Mitsi 2007[28] |
Greece | Caucasian | Unclassified | I-III | 95 | IHC | NA | 17/95 | 66(0.4–89.3) (median) |
PFS | 1.44 (0.79–2.63) |
Indirectly | 7 |
| Brozek 2006 [31] |
Gdansk | Caucasian | Unclassified | I-IV | 53 | FISH | NA | 10/53 | NA | OS | 2.44 (0.79–7.52) |
Indirectly | 6 |
| Surowiak 2006 [29] |
Germany | Caucasian | Unclassified | I-III | 43 | IHC | 51 (mean) |
21/43 | 0–52 |
OS | 0.85 (0.17–4.33) |
Indirectly | 7 |
| Castellvi 2006 [30] |
Spain | Caucasian | Unclassified | I-IV | 75 | IHC | 55(20–87) (mean) |
23/75 | 31(24–80) (mean) |
OS | 1.12 (0.49–2.54) |
Indirectly | 7 |
| Verri 2005 [32] |
Italy | Caucasian | Unclassified | I-IV | 194 | IHC | 57(25–90) median |
53/194 | 45(1–161) (median) |
OS | 1.36 (0.76–2.42) |
Directly | 8 |
| Verri 2005 [32] |
Italy | Caucasian | Unclassified | I-IV | 194 | IHC | 57(25–90) median |
53/194 | 45(1–161) (median) |
PFS | 1.61 (0.94–2.73) |
Directly | 8 |
| Lassus 2004 [34] |
Sweden | Caucasian | Serous | I-IV | 401 | CISH | NA | 66/401 | NA | OS | 2.14 (1.34–3.42) |
Directly | 7 |
| Nielsen 2003 [33] |
Denmark | Caucasian | Unclassified | I-IV | 783 | IHC | 58(13–91) (median) |
272/783 | NA | OS | 0.95 (0.66–1.36) |
Directly | 7 |
| Camilleri-Broet 2004 [35] |
France | Caucasian | Unclassified | IIIA-IV | 95 | IHC | 59(23–74) median |
15/95 | 68 (median) |
OS | 2.12 (1.13–3.98) |
Directly | 7 |
| Camilleri-Broet 2004 [35] |
France | Caucasian | Unclassified | IIIA-IV | 95 | IHC | 59(23–74) median |
15/95 | 68 (median) |
PFS | 1.99 (1.12–3.54) |
Directly | 7 |
| Skirnisdottir 2001[36] |
Sweden | Caucasian | Unclassified | IA-IIC | 106 | IHC | 60(26–82) mean |
20/106 | 87(57–125) mean |
OS | 2.28 (0.67–7.82) |
Indirectly | 8 |
| Davidson 2000 [37] |
Norway | Caucasian | Unclassified | NA | 75 | IHC | 56.9(30–84) mean |
35/75 | 70(8–224) mean |
OS | 1.92 (1.1–3.37) |
Indirectly | 8 |
| Wang 1999 [38] |
USA | Caucasian | Unclassified | NA | 40 | FISH | 61(35–83) median |
10/40 | 1–56 all |
OS | 4 (1.2–13.9) |
Indirectly | 8 |
| Medl 1995 [39] |
Austria | Caucasian | Unclassified | I-IV | 196 | PCR | 59.6(15–88) median |
79/196 | 59 mean |
OS | 1.08 (0.73–1.6) |
Indirectly | 8 |
| Fajac 1995[40] |
France | Caucasian | Unclassified | I-IV | 65 | South blot | 52 mean |
9/65 | 71 (10–43) median |
OS | 1.8 (0.75–4.33) |
Indirectly | 7 |
| Berchuck 1990 [41] |
USA | Caucasian | Unclassified | NA | 73 | IHC | 63.5 (median) |
23/73 | 1–100 (all) |
OS | 4.39 (2.13–9.06) |
Inirectly | 8 |
Abbreviations: HR: hazard ratio, CI: confidence interval, IHC: immunohistochemistry, FISH: fluorescence in situ hybridization. ELISA: enzyme-linked immunosorbent assay, CISH: chromogenic in situ hybridization, PCR: polymerase chain reaction, NA: not available, OS: overall survival, DFS/PFS: disease-free survival/ progress-free survival, Serous: serous ovarian cancer, Unclassified: serous, mucinous, clear cell, endometrioid, transitional cell, undifferentiated, differentiated, and others.