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| Compound | 6-α-aminocholestanol | 6-β-aminocholestanol | 6-ketocholestanol | |
|---|---|---|---|---|
| Estimated free energy of binding | LieIF | -9.1 | -7.2 | -7.7 |
| Phos-LieIF | -6.9 | -6.6 | -7.9 | |
| eIF4AI | -5.5 | -3.5 | -4.1 | |
| Estimated Ki (μM) | LieIF | 211.6 10−3 | 5.3 | 2.2 |
| Phos-LieIF | 8.9 | 14.5 | 1.7 | |
| eIF4AI | 94.5 | 2.6 103 | 973.6 | |
