Figure 2. Effect of long term growth hormone therapy on adult height in randomised controlled trials. Results of meta-analysis according to random model (69) in children with idiopathic short stature (ISS). The mean difference in adult height between treated and untreated ISS children was 0.65 standard deviation (IC 95% 0.4-0.91, p<0.001) SD: standard deviation, RCT: randomized controlled trial.