Figure 6.
rCCL3 or irradiated L3TU significantly slows established tumor growth. Mice were injected with 1 × 106 WTTU cells in the left flank. 7 days later mice were injected in the footpad or intra-tumorally (i.t.) with whole tumor lysate from lethally irradiated WTTU (iWT) or L3TU (iL3), or recombinant CCL3 (rCCL3; 100 ng). A, WTTU tumor growth in mice that received whole cell lysates of iWT or iL3. B, Tumor growth in mice that received either i.t. or s.c. injections of rCCL3. Subcutaneous injections were administered either ipsilaterally (ipsi) or contralaterally (contra) relative to WTTU 7-days post tumor injection (R7). Data shown as compilation of 2 independent experiments with n = 5–10 mice per group. NS: not significant; *, P = 0.01 to 0.05; **, P = 0.001 to 0.01; ***, P = 0.0001 to 0.001; ****, P < 0.0001. Standard error is shown as SD.