Table 1.

PD-L1 expression in tumor cells and tumor-infiltrating lymphocytes and CD274/PD-L1 copy number status in high-grade sarcomas of soft-tissue; Mean and median value of cases with PD-L1 positive TCs respectively TILs are shown. TC Tumor cell; TIL Tumor-infiltrating lymphocyte; UPS Undifferentiated pleomorphic sarcoma; ASPS Alveolar soft part sarcoma; ES Epithelioid sarcoma AS Angiosarcoma; LMS Leiomyosarcoma; SS Synovial sarcoma.

	Number of Cases	PD-L1 positive TCs			PD-L1 positive TILs			CD274/PD-L1 Copy Number
								Amplification	Polysomy	Disomy	Deletion
	n	n (%)	Mean (%); Median (%)	Range (%)	n (%)	Mean (%); Median (%)	Range (%)	n (%)	n (%)	n (%)	n (%)
UPS	57	23 (40.4)	24.9; 10.0	0.0–90.0	10 (17.5)	23.1; 15.0	0.0–50.0	8 (14.0)	26 (45.6)	22 (38.6)	1 (1.8)
ASPS	5	1 (20.0)	70.0; 70.0	0.0–70.0	1 (20.0)	0.5; 0.5	0.0–0.5	0 (0.0)	1 (3.3)	29 (96.7)	0 (0.0)
ES	5	1 (20.0)	5.0; 5.0	0.0–5.0	1 (20.0)	5.0; 5.0	0.0–5.0	1 (4.3)	3 (13.0)	19 (82.6)	0 (0.0)
AS	23	8 (34.8)	25.4; 7.5	0.0–80.0	2 (8.7)	5.5; 5.5	0.0–10.0	0 (0.0)	5 (62.5)	2 (25.0)	1 (12.5)
LMS	8	1 (11.1)	3.0; 3.0	0.0–3–0	0 (0.0)			0 (0.0)	1 (20.0)	4 (80.0)	0 (0.0)
SS	30	2 (6.7)	10.5; 10.5	0.0–20.0	1 (3.3)	10.0; 10.0	0.0–10.0	0 (0.0)	0 (0.0)	5 (100.0)	0 (0.0)
p-value		0.012			0.238			<0.001