Figure 2.

Peripheral blood T cells and cutaneous infiltrating T cells do not share the same major T cell clones after treatment with moga (A, B) PBMCs, sorted CD4⁺/CD8⁺ T cells, and skin tissues were subjected to TCR repertoire analysis in two ATL cases with moga-related skin rash. 3D graphs show the frequencies of TRAV/J clones. In panel A, the blue bar consists of three clones with different amino acid sequences in the CDR3 region, but sharing TRAV24/J52. H&E and CD3/4/8 staining of the samples of tissue from the skin rash are also shown. Data are representative of four independent patients.