Table 1.
Gene set enrichment analysis. Enrichment analysis of gene sets identified by RNA sequencing of genetically targeting of AKT and WEE1 pathways in UACC 903 cells. For the full list, please see Supplementary Table 4.
| Treatment | Subgroup | Pathway/Transcription Factor | p-Value | Z Score | Combined Score | Tool | |
|---|---|---|---|---|---|---|---|
| 1 | siWEE1 | DOWN | FOXM1 | 5.00E-14 | −2.70 | 68.11 | CHEA |
| 2 | siWEE1 | DOWN | E2F4 | 1.40E-06 | −2.84 | 26.12 | CHEA |
| 3 | siWEE1 | UP | TP63 | 3.89E-09 | −4.14 | 61.69 | CHEA |
| 4 | siWEE1 | UP | TP53 | 4.30E-12 | −2.00 | 41.32 | CHEA |
| 5 | siWEE1 | ALL | M Phase | 1.82E-03 | −2.30 | 5.61 | REACTOME |
| 6 | siWEE1 | ALL | DNA Damage Response | 2.00E-03 | −1.83 | 6.80 | WIKIPATHWAYS |
| 7 | siWEE1 | ALL | TP53 Network | 2.93E-03 | −1.45 | 5.38 | WIKIPATHWAYS |
| 8 | siWEE1+siAKT3 | DOWN | FOXM1 | 5.73E-09 | −2.70 | 36.85 | CHEA |
| 9 | siWEE1+siAKT3 | DOWN | E2F4 | 1.63E-04 | −2.76 | 15.13 | CHEA |
| 10 | siWEE1+siAKT3 | UP | GATA3 | 2.19E-03 | −1.85 | 4.05 | ENCODE |
| 11 | siWEE1+siAKT3 | ALL | RB in Cancer | 1.38E-03 | −1.92 | 5.44 | WIKIPATHWAYS |
| 12 | siWEE1+siAKT3 | ALL | M Phase | 9.25E-04 | −2.30 | 6.86 | REACTOME |
| 13 | siWEE1+siAKT3 | ALL | Validated transcriptional targets of TAp63 isoforms | 2.89E-05 | −1.70 | 11.82 | NCI NATURE |
| 14 | siWEE1+siAKT3 | ALL | Direct p53 effectors | 2.19E-03 | −1.59 | 5.94 | NCI NATURE |
| 15 | siWEE1+siAKT3 | ALL | PLK1 signaling events | 3.91E-03 | −1.44 | 4.95 | NCI NATURE |
| 16 | siWEE1+siAKT3 | ALL | class I PI3K signaling events mediated by Akt | 2.56E-02 | −1.19 | 2.34 | NCI NATURE |