Figure 1.

Mice were separated into four treatment groups; Sham, DEX, CA, and DEX + CA as described in the methods section. Mice in the Sham and CA groups were injected subcutaneously with NS on D1 to D8 of each treatment cycle (filled arrows). Mice in the DEX and DEX + CA groups were injected sq with 5 mg/kg DEX on days one to five, 2.5 mg/kg DEX on d 6 and 7, and 1.25 mg/kg on D 8. On Treatment D 3 (D3) mice in the CA and DEX + CA groups were injected i.p. with Cytoxan + Adriamycin (CA) while mice in the Sham and DEX groups were injected with the same volume of normal saline (NS).