Figure 2.
Poly(I:C) drives an immunostimulatory secretome of primary human glioblastoma cells. Poly(I:C) enhances the release of type I IFN, IL-15 and chemokines by primary glioblastoma cells, while TGF-β secretion is inhibited. IFN-γ secretion is not induced; n = 6–8; Friedman test with Bonferroni correction. 10µg/ml poly(I:C) and 5000IU/ml IFN-γ were used. Bar represents median. Symbols depict primary glioblastoma cells derived from different glioblastoma patients. Grey symbols represent data points above the detection limit; these were capped at the detection limit for visualization and analysis purposes since differences were apparent. **, p < 0.01; ***, p < 0.001.