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. 2017 Nov 27;7(3):e1395996. doi: 10.1080/2162402X.2017.1395996

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Figure 3. — 8Gyx2 and 2Gyx10 IR variably alters tumor and peripheral accumulation of immunosuppressive cell subsets. Primary tumor and splenic tissues (n = 5/time point) were harvested and analyzed as in Fig. 2. A, Immunosuppressive immune cell accumulation in MOC1 primary tumors and spleen. B, Immunosuppressive immune cell accumulation in MC38-CEA primary tumors and spleen. Quantification of tumor accumulation of cells presented as absolute number of cells per 1 × 10⁴ live cells analyzed. Quantification of splenic accumulation of cells presented as percentage of live, CD45.2⁺ cells analyzed. Cell subset definitions included gMDSC (CD11b⁺F4/80⁻Ly6G^hiLy6C^int), mMDSC (CD11b⁺ F4/80⁻Ly6G^lowLy6C^hi) and Tregs (CD3⁺CD4⁺FoxP3⁺CD25^hi). *, p < 0.05; **, p < 0.01; ***, p < 0.001 (t test) compared to control tumors for each time point.