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. 2018 Feb 20;28(6):431–444. doi: 10.1089/ars.2017.7300

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© Bridgette M. Cumming, et al., 2018; Published by Mary Ann Liebert, Inc.

This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.

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FIG. 7. — Functions of EGT in bacteria. This figure illustrates functions of ergothioneine in various bacteria, such as maintaining bioenergetic homeostasis in Mycobacterium tuberculosis, modulating susceptibility of M. tuberculosis toward TB drug, protection against diverse oxidative stressors in M. tuberculosis, Methylobacterium aquaticum, and Streptomyces coelicolor, resistance against alkylating agents and metals in M. smegmatis, and defense against heat shock and UV irradiation in M. aquaticum. EGT is essential for survival of M. tuberculosis in macrophages and virulence of M. tuberculosis in mice.