Table 2. Univariate and multivariate cox regression analyses for overall survival and recurrence free survival in localized ccRCC patients.

Variables	Univariate analysis		Multivariate analysis
	HR(95% CI)	p*	HR(95% CI)	p*
Overall survival
pT stage		<0.001		<0.001
pT2 vs pT1	3.70 (1.78-7.68)	<0.001	4.12(1.56-10.89)	0.004
pT3 vs pT1	3.94(2.33-6.67)	<0.001	4.44(2.45-8.04)	<0.001
pT4 vs pT1	10.01(3.01-33.29)	<0.001	10.81(2.98-39.29)	<0.001
Fuhrman grade		<0.001		<0.001
2 vs 1	1.53(0.55-4.27)	0.419	1.15(0.40-3.26)	0.798
3 vs 1	5.35(1.83-15.60)	0.002	3.72(1.24-11.17)	0.019
4 vs 1	7.39(1.65-33.08)	0.009	9.10(1.91-43.31)	0.006
Necrosis (present vs absent)	3.30(1.97-5.51)	<0.001	2.52(1.44-4.44)	0.001
Tumor size (continuous, cm)	1.19(1.09-1.29)	<0.001	0.99(0.88-1.12)	0.858
ECOG PS (≥1 vs 0)	1.303(0.79-2.151)	0.300	-	-
ST6GalNAc-1 (high vs low)	2.51(1.56-4.04)	<0.001	2.74(1.66-4.52)	<0.001
Recurrence-free survival
pT stage		<0.001		<0.001
pT2 vs pT1	4.23(2.09-8.56)	<0.001	4.91(1.88-12.82)	0.001
pT3 vs pT1	3.22(1.88-5.52)	<0.001	4.37(2.67-8.06)	<0.001
pT4 vs pT1	17.87(6.10-52.33)	<0.001	20.22(6.29-65.02)	<0.001
Fuhrman grade		<0.001		<0.001
2 vs 1	1.20(0.47-3.03)	0.704	0.84(0.32-2.18)	0.721
3 vs 1	3.60(1.34-9.66)	0.011	2.85(1.02-8.00)	0.047
4 vs 1	5.89(1.41-24.79)	0.015	6.78(1.52-30.23)	0.012
Necrosis (present vs absent)	3.15(1.87-5.31)	<0.001	2.47(1.39-4.38)	0.002
Tumor size (continuous, cm)	1.19(1.09-1.29)	<0.001	0.99(0.88-1.12)	0.859
ECOG PS (≥1 vs 0)	1.19(0.71-1.99)	0.511	-	-
ST6GalNAc-1 (high vs low)	2.61(1.62-4.22)	<0.001	2.88(1.73-4.79)	<0.001

Abbreviations: ECOG PS: Eastern Cooperative Oncology Group performance status; HR: hazard ratio; CI: confidence interval; ccRCC: clear cell renal cell carcinoma.

*Data obtained from the Cox proportional hazards model; p <0.05 was regard as statistically significant.