Table 2. Comparison of complete remission rates according to the plasma levels of BAFF and APRIL.
Univariate | Multivariate* | |||||
---|---|---|---|---|---|---|
Marker | Group | Level (ng/mL) | HR (95% CI) | P | HR (95% CI) | P |
BAFF | 1st tertile (n = 29) | 0.7 ± 0.12 | 1 (Reference) | 1 (Reference) | ||
2nd tertile (n = 30) | 0.9 ± 0.05 | 0.96 (0.514–1.785) | 0.891 | 0.98 (0.465–2.066) | 0.958 | |
3rd tertile (n = 30) | 1.2 ± 0.25 | 1.02 (0.546–1.905) | 0.952 | 0.80 (0.360–1.770) | 0.580 | |
APRIL | Undetectable (n = 53) | 0 | 1 (Reference) | 1 (Reference) | ||
Low (n = 18) | 0.3 (0.07–0.47) | 0.76 (0.399–1.447) | 0.403 | 0.83 (0.347–1.958) | 0.662 | |
High (n = 18) | 1.6 (1.21–3.13) | 0.40 (0.176–0.887) | 0.024 | 0.23 (0.076–0.706) | 0.010 |
*Adjusted for age, sex, hypertension, diabetes mellitus, baseline creatinine, albumin, cholesterol, urine protein to creatinine ratio, estimated glomerular filtration rate, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, steroids, cyclophosphamides or other immunosuppressive agents, pathologic stage, and tubulointerstitial fibrosis.
Abbreviations: BAFF, B-cell activating factor; APRIL, a proliferation-inducing ligand; HR, hazard ratio; CI, confidence interval.