Table 3. Hazard ratios for relapse after treatment response according to the levels of BAFF and APRIL.
Univariate | Multivariate* | |||||
---|---|---|---|---|---|---|
Marker | Group | Level (ng/mL) | HR (95% CI) | P | HR (95% CI) | P |
BAFF | 1st tertile (n = 24) | 0.7 ± 0.12 | 1 (Reference) | 1 (Reference) | ||
2nd tertile (n = 27) | 0.9 ± 0.06 | 0.59 (0.136–2.523) | 0.472 | 0.85 (0.151–4.796) | 0.851 | |
3rd tertile (n = 28) | 1.2 ± 0.26 | 3.13 (1.016–9.670) | 0.047 | 5.57 (1.394–22.258) | 0.015 | |
APRIL | Undetectable (n = 50) | 0 | 1 (Reference) | 1 (Reference) | ||
Low (n = 16) | 0.3 (0.07–0.60) | 1.37 (0.458–4.091) | 0.570 | 0.96 (0.280–3.299) | 0.961 | |
High (n = 13) | 1.6 (1.23–2.93) | 1.08 (0.294–3.967) | 0.904 | 0.99 (0.174–5.645) | 0.990 |
*Adjusted for age, sex, hypertension, diabetes mellitus, baseline creatinine, albumin, cholesterol, urine protein to creatinine ratio, estimated glomerular filtration rate, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, steroids, cyclophosphamides or other immunosuppressive agents, pathologic stage, and tubulointerstitial fibrosis.
Abbreviations: BAFF, B-cell activating factor; APRIL, a proliferation-inducing ligand; HR, hazard ratio; CI, confidence interval.