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. 2017 Dec 14;9(3):3292–3302. doi: 10.18632/oncotarget.23232

Table 3. Hazard ratios for relapse after treatment response according to the levels of BAFF and APRIL.

Univariate Multivariate*
Marker Group Level (ng/mL) HR (95% CI) P HR (95% CI) P
BAFF 1st tertile (n = 24) 0.7 ± 0.12 1 (Reference) 1 (Reference)
2nd tertile (n = 27) 0.9 ± 0.06 0.59 (0.136–2.523) 0.472 0.85 (0.151–4.796) 0.851
3rd tertile (n = 28) 1.2 ± 0.26 3.13 (1.016–9.670) 0.047 5.57 (1.394–22.258) 0.015
APRIL Undetectable (n = 50) 0 1 (Reference) 1 (Reference)
Low (n = 16) 0.3 (0.07–0.60) 1.37 (0.458–4.091) 0.570 0.96 (0.280–3.299) 0.961
High (n = 13) 1.6 (1.23–2.93) 1.08 (0.294–3.967) 0.904 0.99 (0.174–5.645) 0.990

*Adjusted for age, sex, hypertension, diabetes mellitus, baseline creatinine, albumin, cholesterol, urine protein to creatinine ratio, estimated glomerular filtration rate, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, steroids, cyclophosphamides or other immunosuppressive agents, pathologic stage, and tubulointerstitial fibrosis.

Abbreviations: BAFF, B-cell activating factor; APRIL, a proliferation-inducing ligand; HR, hazard ratio; CI, confidence interval.