Table 1. Comparison of DTX concentration sin plasma and various tissues between TxR mice treated with DTX and combination of DTX and PIP.
Groups | Tissue concentration (ng/mg) | Plasma concentration (ng/ml) |
||||
---|---|---|---|---|---|---|
Tumor | Brain | Kidney | Lung | Liver | ||
TxR-DTX (n = 10) | 1.312 ± 0.754 | 0.022 ± 0.009 | 2.322 ± 1.447 | 5.158 ± 2.886 | 1.080 ± 0.763 | 703.847 ± 311.129 |
TxR-DTX+PIP (n = 10) | 5.854 ± 5.510* | 0.051 ± 0.047 | 5.980 ± 5.234 | 4.991 ± 3.133 | 2.782 ± 0.891** | 1448.432 ± 698.493** |
Note: Comparisons were conducted by Student’s T-test. *p < 0.05; **p < 0.01; ***p < 0.001.
Abbreviation: DTX = docetaxel; PIP = piperine.