Table 2B. Causes of death by time period after transplant.
MAC | RIC | ||||
---|---|---|---|---|---|
TBF | BF | TBF | BF | ||
Before day 100 | Total | 14 | 184 | 8 | 157 |
Infection | 4 (29%) | 39 (21%) | 3 (38%) | 20 (13%) | |
GVHD | 4 (29%) | 31 (17%) | 0 | 24 (15%) | |
Original disease | 2 (14%) | 89 (49%) | 3 (38%) | 100 (65%) | |
Cardiac toxicity | 0 | 0 | 1 (13%) | 1 (1%) | |
Haemorhage | 1 (7%) | 1 (1%) | 0 | 1 (1%) | |
Failure/Rejection | 0 | 2 (1.1%) | 0 | 0 | |
VOD | 2 (14%) | 8 (4%) | 0 | 0 | |
Interstitial Pneumonitis | 0 | 2 | 1 (13%) | 1 (1%) | |
Second malignancy | 0 | 0 | 0 | 0 | |
Other transplantation related | 1 (7%) | 10 (5%) | 0 | 8 (5%) | |
Missing | 0 | 2 | 0 | 2 | |
From day 100 to 2 years | Total | 25 | 274 | 8 | 259 |
Original disease | 9 (38%) | 141 (54%) | 4 (57%) | 112 (46%) | |
GVHD | 8 (33%) | 59 (23%) | 3 (43%) | 71 (29%) | |
Infection | 5 (21%) | 44 (17%) | 0 | 44 (18%) | |
Haemorhage | 0 | 0 | 0 | 2 (1%) | |
Failure/Rejection | 0 | 0 | 0 | 2 (1%) | |
VOD | 0 | 0 | 0 | 0 | |
Cardiac toxicity | 0 | 1 (1%) | 0 | 0 | |
Interstitial Pneumonitis | 0 | 4 (2% ) | 0 | 2 (1% ) | |
Second malignancy | 1 (4% ) | 1 (1% ) | 0 | 3 (1% ) | |
Other transplantation related | 1 (4% ) | 10 (4% ) | 0 | 8 (3% ) | |
Missing | 1 | 14 | 1 | 15 |
Abbreviations: BF, busulfan-fludarabine; GVHD, graft-versus-host disease; MAC, myeloablative conditioning; RIC, reduced-intensity conditioning; TBF, thiotepa-busulfan-fludarabine; VOD, veno-occlusive disease.