Figure 11. Protein expression of anti-oxidative stress, anti-inflammatory and mitochondrial integrity biomarkers in LV myocardium by day 5 after BD-derived tissue implantation.

(A) Protein expression of sirtuin 1 (SIRT1), ^* vs. other groups with different symbols (^†, ^‡, ^§), p < 0.0001. (B) Protein expression of SIRT3, ^* vs. other groups with different symbols (^†, ^‡, ^§), p < 0.0001. (C) The protein expression of interleukin (IL)-10, ^* vs. other groups with different symbols (^†, ^‡, ^§), p < 0.0001. (D) Protein expression of IL-4, ^* vs. other groups with different symbols (^†, ^‡, ^§), p < 0.0001. (E) Protein expression of mitochondrial cytochrome C (mit-Cyt C), ^* vs. other groups with different symbols (^†, ^‡), p < 0.0001. (F) Protein expression of cytosolic cytochrome C (mit-Cyt C), ^* vs. other groups with different symbols (^†, ^‡, ^§), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6). Symbols (^*, ^†, ^‡, ^§) indicate significance (at 0.05 level). NC = normal control; SC = sham control; BD_EX = brain death extract; Mel = melatonin; Luz = luzindole.