Table 2. Distribution of genotype/allele frequency of three SNPs in HOTAIR and their correlations with breast cancer.
| Genotype | Cases (n = 969) no.(%) | Controls (n = 970) no.(%) | P | Adjusted OR (95% CI)a |
P trendb |
|---|---|---|---|---|---|
| rs1899663 G>T | |||||
| GG | 628 | 665 | 1.00 (Reference) | ||
| GT | 299 | 284 | 0.326 | 1.11 (0.91–1.35) | |
| TT | 42 | 21 | 0.009 | 2.08 (1.20–3.60) | 0.027 |
| GT + TT | 341 | 305 | 0.109 | 1.17 (0.97–1.42) | |
| T allele frequency | 383 (19.8) | 326 (16.8) | 0.017c | ||
| rs4759314 A>G | |||||
| AA | 801 | 817 | 1.00 (Reference) | ||
| GA | 157 | 144 | 0.536 | 1.08 (0.84–1.39) | |
| GG | 11 | 9 | 0.805 | 1.12 (0.45–2.80) | 0.520 |
| GA + GG | 168 | 153 | 0.514 | 1.08 (0.85–1.39) | |
| A allele frequency | 179 (9.2) | 162 (8.4) | 0.338c | ||
| rs7958904 G>C | |||||
| GG | 489 | 537 | 1.00 (Reference) | ||
| GC | 396 | 373 | 0.171 | 1.14 (0.94–1.38) | |
| CC | 84 | 60 | 0.046 | 1.45 (1.01–2.08) | 0.030 |
| GC + CC | 480 | 433 | 0.068 | 1.19 (0.99–1.42) | |
| C allele frequency | 564 (29.1) | 493 (25.4) | 0.010c |
aAdjusted by age, BMI, age at menarche, menopausal status and family history of breast cancer where appropriate.
bP trend for genotypes between cases and controls.
cTwo-sided χ2 test for differences in allele frequency distributions between cases and cancer-free controls.