Table 3. Stratified analysis on associations among rs1899663 and rs7958904 polymorphisms and breast cancer risk.
| Characteristics | rs1899663 | P | OR (95% CI)a | Pb | rs7958904 | P | OR (95% CI)a | Pb | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases ( GG/GT + TT) |
Controls (GG/GT + TT) |
Cases (GG/GC + CC) |
Controls (GG/GC + CC) |
|||||||
| Age | 0.155 | 0.525 | ||||||||
| ≤40 | 164/112 | 192/89 | 0.031 | 1.48 (1.04–2.12) | 129/147 | 153/128 | 0.118 | 1.31 (0.93–1.85) | ||
| >40 | 464/229 | 473/216 | 0.662 | 1.05 (0.84–1.33) | 360/333 | 384/305 | 0.250 | 1.14 (0.91–1.41) | ||
| BMI | 0.793 | 0.319 | ||||||||
| ≤24 | 451/250 | 436/212 | 0.247 | 1.15 (0.91–1.44) | 343/358 | 355/293 | 0.040 | 1.26 (1.01–1.57) | ||
| >24 | 177/91 | 229/93 | 0.283 | 1.22 (0.85–1.75) | 146/122 | 182/140 | 0.868 | 1.03 (0.73–1.44) | ||
| Age at menarche | 0.100 | 0.503 | ||||||||
| ≤15 | 314/182 | 349/149 | 0.019 | 1.38 (1.05–1.82) | 244/252 | 274/224 | 0.074 | 1.26 (0.98–1.63) | ||
| >15 | 314/159 | 316/156 | 0.902 | 0.98 (0.74–1.30) | 245/228 | 263/209 | 0.450 | 1.11 (0.85–1.44) | ||
| Menopausal status | 0.649 | 0.490 | ||||||||
| Premenopausal | 402/218 | 426/198 | 0.261 | 1.15 (0.90–1.46) | 310/310 | 350/274 | 0.056 | 1.25 (0.99–1.57) | ||
| Postmenopausal | 220/122 | 227/100 | 0.162 | 1.27 (0.91–1.78) | 174/168 | 175/152 | 0.605 | 1.09 (0.79–1.49) | ||
| Age at menopause | 0.624 | 0.434 | ||||||||
| ≤50 | 87/56 | 118/49 | 0.471 | 1.19 (0.75–1.89) | 104/95 | 88/79 | 0.862 | 0.96 (0.63–1.48) | ||
| >50 | 133/66 | 109/51 | 0.163 | 1.42 (0.87–2.31) | 70/73 | 87/73 | 0.327 | 1.26 (0.79–2.03) | ||
| Age at first live birth | 0.129 | 0.057 | ||||||||
| ≤25 | 329/195 | 445/198 | 0.017 | 1.36 (1.06–1.75) | 251/273 | 362/281 | 0.010 | 1.37 (1.08–1.74) | ||
| >25 | 270/137 | 191/96 | 0.930 | 0.99 (0.71–1.37) | 216/191 | 149/138 | 0.677 | 0.94 (0.69–1.28) | ||
| ER status | 0.532 | 0.084 | ||||||||
| Positive | 415/229 | 0.057 | 1.23 (0.99–1.53) | 313/331 | 0.009 | 1.32 (1.07–1.61) | ||||
| Negative | 213/112 | 0.480 | 1.10 (0.84–1.45) | 176/149 | 0.931 | 0.99 (0.76–1.28) | ||||
| PR status | 0.923 | 0.148 | ||||||||
| Positive | 369/197 | 0.113 | 1.20 (0.96–1.50) | 275/291 | 0.010 | 1.32 (1.07–1.64) | ||||
| Negative | 259/144 | 0.187 | 1.18 (0.92–1.52) | 214/189 | 0.724 | 1.04 (0.82–1.32) | ||||
aAdjusted by age, BMI, age at menarche, menopausal status and family history of breast cancer where appropriate.
bP for heterogeneity test.