Table 5. Stratified analysis of HOTAIR rs1899663 genotypes on DFS and OS of breast cancer patients.
| Variable | Disease free survival Genotypes (Relapse/Patients) |
Overall survival Genotypes (Death/Patients) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GG | HR (95% CI) | GT + TT | HR (95% CI)a* | Log-rank p | GG | HR (95% CI) | GT + TT | HR (95% CI)a* | Log-rank p | |
| Age | ||||||||||
| ≤40 | 54/164 | 1.00 | 54/112 | 1.64 (1.12–2.40) | 0.010 | 28/164 | 1.00 | 38/112 | 2.10 (1.29–3.42) | 0.003 |
| >40 | 163/464 | 1.00 | 66/229 | 0.80 (0.60–1.07) | 0.130 | 109/464 | 1.00 | 42/229 | 0.78 (0.54–1.12) | 0.175 |
| Tumor size | ||||||||||
| ≤2 cm | 50/244 | 1.00 | 31/141 | 1.09 (0.70–1.71) | 0.700 | 33/244 | 1.00 | 20/141 | 1.05 (0.60–1.83) | 0.875 |
| >2 cm | 167/384 | 1.00 | 89/200 | 1.05 (0.81–1.36) | 0.719 | 104/384 | 1.00 | 60/200 | 1.14 (0.83–1.57) | 0.407 |
| Lymph node involvement | ||||||||||
| No | 66/322 | 1.00 | 38/157 | 1.21 (0.81–1.80) | 0.356 | 33/322 | 1.00 | 17/157 | 1.09 (0.61–1.95) | 0.779 |
| Yes | 151/306 | 1.00 | 82/184 | 0.87 (0.66–1.14) | 0.304 | 104/306 | 1.00 | 63/184 | 1.04 (0.76–1.43) | 0.807 |
| Molecular subtype | ||||||||||
| Luminal type | 125/415 | 1.00 | 66/229 | 0.95 (0.70–1.28) | 0.727 | 70/415 | 1.00 | 39/229 | 1.04 (0.70–1.54) | 0.861 |
| HER-2 overexpression | 41/98 | 1.00 | 24/51 | 1.24 (0.75–2.05) | 0.411 | 29/98 | 1.00 | 17/51 | 1.22 (0.67–2.22) | 0.512 |
| TNBC | 51/115 | 1.00 | 30/61 | 1.12 (0.71–1.77) | 0.616 | 38/115 | 1.00 | 24/61 | 1.18 (0.70–1.96) | 0.536 |
aCox regression analyses for DFS and OS in breast cancer patients according to dominant model.
*Adjusted by age, tumor size, lymph node status, ER,PR and Her-2 status where appropriate.