Table 6. Stratified analysis of HOTAIR rs4759314 genotypes on DFS and OS of breast cancer patients.
| Variable | Disease free survival Genotypes (Relapse/Patients) |
Overall survival Genotypes (Death/Patients) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA | HR (95% CI) | GA + GG | HR (95% CI)a* | Log-rank p | AA | HR (95% CI) | GA + GG | HR (95% CI)a* | Log-rank p | |
| Age | ||||||||||
| ≤40 | 85/223 | 1.00 | 23/53 | 1.06 (0.67–1.68) | 0.806 | 52/223 | 1.00 | 14/53 | 1.03 (0.57–1.87) | 0.919 |
| >40 | 190/578 | 1.00 | 39/115 | 0.97 (0.69–1.37) | 0.871 | 127/578 | 1.00 | 24/115 | 0.86 (0.56–1.33) | 0.501 |
| Tumor size | ||||||||||
| ≤2 cm | 65/318 | 1.00 | 16/67 | 1.09 (0.63–1.88) | 0.768 | 46/318 | 1.00 | 7/67 | 0.63 (0.28–1.40) | 0.254 |
| >2 cm | 210/483 | 1.00 | 46/101 | 0.99 (0.71–1.36) | 0.926 | 133/483 | 1.00 | 31/101 | 1.05 (0.71–1.56) | 0.803 |
| Lymph node involvement | ||||||||||
| No | 90/394 | 1.00 | 14/85 | 0.99 (0.97–1.01) | 0.331 | 47/394 | 1.00 | 3/85 | 0.26 (0.08–0.83) | 0.023 |
| Yes | 185/407 | 1.00 | 48/83 | 1.29 (0.94–1.78) | 0.115 | 132/407 | 1.00 | 35/83 | 1.20 (0.83–1.76) | 0.334 |
| Molecular subtype | ||||||||||
| Luminal type | 151/521 | 1.00 | 40/123 | 1.05 (0.74–1.49) | 0.780 | 89/521 | 1.00 | 20/123 | 0.85 (0.52–1.38) | 0.498 |
| HER-2 overexpression | 54/128 | 1.00 | 11/21 | 1.37 (0.71–2.64) | 0.347 | 36/128 | 1.00 | 10/21 | 1.95 (0.96–3.96) | 0.064 |
| TNBC | 70/152 | 1.00 | 11/24 | 0.89 (0.47–1.69) | 0.724 | 54/152 | 1.00 | 8/24 | 0.77 (0.36–1.63) | 0.488 |
aCox regression analyses for DFS and OS in breast cancer patients according to dominant model.
*Adjusted by age, tumor size, lymph node status, ER,PR and Her-2 status where appropriate.