Table 2. Correlations of AR, CD44+/CD24-/low and let-7a with clinicopathological and biological characteristics.
| Clinicopathological and biological characteristics | Total cases (N = 165) |
CD44+/CD24-/low present | AR positive | let7a positive | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| % (N = 59) | χ2 |
P value |
% (N = 121) | χ2 | P value | % (N = 118) | χ2 | P value | ||
| Age (years) | ||||||||||
| < 35 | 2 | 100.0 (2) | 3.920 | 0.141 | 100.0 (2) | 1.635 | 0.442 | 50.0 (1) | 0.520 | 0.771 |
| 35-49 | 79 | 32.9 (26) | 69.6 (55) | 70.9 (56) | ||||||
| > 49 | 84 | 36.9 (31) | 76.2 (64) | 72.6 (61) | ||||||
| Histological grade | ||||||||||
| G1 | 20 | 20.0 (4) | 2.465 | 0.292 | 75.0 (15) | 7.557 | 0.023 | 85.0 (17) | 2.050 | 0.359 |
| G2 | 77 | 37.7 (29) | 63.6 (49) | 70.1 (54) | ||||||
| G3 | 68 | 38.2 (26) | 83.8 (57) | 69.1 (47) | ||||||
| Tumor size (cm) | ||||||||||
| ≤ 2 | 50 | 22.0 (11) | 16.386 | < 0.001 | 80.0 (40) | 4.752 | 0.093 | 80.0 (40) | 3.329 | 0.189 |
| 2 < & ≤ 5 | 98 | 35.7 (35) | 73.5 (72) | 69.4 (68) | ||||||
| > 5 | 17 | 76.5 (13) | 52.9 (9) | 58.8 (10) | ||||||
| Lymph node status | ||||||||||
| negative | 73 | 17.8 (13) | 18.362 | < 0.001 | 75.3 (55) | 0.270 | 0.603 | 83.6 (61) | 9.327 | 0.002 |
| positive | 92 | 50.0 (46) | 71.7 (66) | 62.0 (57) | ||||||
| pTNM stage | ||||||||||
| I | 24 | 33.3 (8) | 0.168 | 0.919 | 75.0 (18) | 2.389 | 0.303 | 83.3 (20) | 8.307 | 0.016 |
| II | 99 | 35.4 (35) | 76.8 (76) | 75.8 (75) | ||||||
| III | 42 | 38.1 (16) | 64.3 (27) | 54.8 (23) | ||||||
| ER | ||||||||||
| negative | 93 | 24.7 (23) | 11.280 | 0.001 | 65.6 (61) | 6.532 | 0.011 | 71.0 (66) | 0.031 | 0.859 |
| positive | 72 | 50.0 (36) | 83.3 (60) | 72.2 (52) | ||||||
| PR | ||||||||||
| negative | 96 | 28.1 (27) | 5.822 | 0.016 | 68.8 (66) | 2.466 | 0.116 | 69.8 (67) | 0.335 | 0.563 |
| positive | 69 | 46.4 (32) | 79.7 (55) | 73.9 (51) | ||||||
| Ki67 | ||||||||||
| < 20% | 55 | 5.4 (3) | 32.979 | < 0.001 | 74.5 (41) | 0.062 | 0.803 | 87.3 (48) | 10.056 | 0.002 |
| ≥ 20% | 110 | 50.9 (56) | 72.7 (80) | 63.6 (70) | ||||||
| HER2 | ||||||||||
| negative | 116 | 32.8 (38) | 1.529 | 0.216 | 69.0 (80) | 3.811 | 0.051 | 74.1 (86) | 1.319 | 0.251 |
| positive | 49 | 42.9 (21) | 83.7 (41) | 65.3 (32) | ||||||
| Molecular subtypes | ||||||||||
| Luminal A | 19 | 0.0 (0) | 43.260 | < 0.001 | 89.5 (17) | 9.116 | 0.028 | 94.7 (18) | 9.766 | 0.021 |
| Luminal B | 59 | 66.1 (39) | 78.0 (46) | 64.4 (38) | ||||||
| HER2 overexpression |
36 | 33.3 (12) | 77.8 (28) | 63.9 (23) | ||||||
| Triple negative | 51 | 15.7 (8) | 58.8 (30) | 76.5 (39) | ||||||