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. 2017 Dec 17;9(3):3779–3793. doi: 10.18632/oncotarget.23375

Figure 2. Functional NHEJ in the MMC-resistant individuals.

Figure 2

(A, B) Survival of the father, mother, sister, a healthy control and a Cernunnos deficient patient exposed to increasing doses of ionizing radiations (A) or phleomycin (B). Results shown as mean ± SD of duplicates are representative of three independent experiments. (C, D) Primary fibroblasts from the father, mother, sister, a healthy control and a Cernunnos deficient patient (Cernu–/–) were either left untreated or irradiated with 0.5 Gy and further incubated for 1 or 24 h before fixation and 53BP1 immunostaining. (C) Representative images of 53BP1 staining. (D) Number of 53BP1 foci per cell (mean ± SEM) quantified in at least 50 nuclei from 3 independent experiments.