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(A) Sanger sequencing showing a heterozygous 94C>T mutation in the ATM gene for the mother, P1 and its sister. (B) CRISPR-Cas9 target sequence in exon 3 of human ATM. (C) MMC survival of a healthy control, the father, the mother and clones #1, 2,11 and 14. Results shown as mean ± SD of duplicates are representative of 3 independent experiments.
