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. 2017 Dec 17;9(3):3794–3804. doi: 10.18632/oncotarget.23376

Figure 3. Anti-tumor and anti-metastasis effects of BA in vivo.

Figure 3

(A) Represented weight of tumor from mice of different groups (vehicle and BA (10 mg/kg/day)), respectively. Data were mean ± SD (n = 6; *P < 0.05). (B) Tumor volume were measured and calculated every three days and presented as mean ± SD (n = 6; *P < 0.05, **P < 0.01). (C) The number of metastasis from lungs. Data were mean ± SD (n = 6; *P < 0.05). (D) The lungs weight of different groups. Results were mean ± SD (n = 6; **P < 0.01). (E) Immunohistochemistry was performed to measure the expression of MMP-2, MMP-9, Ki67 and P-Stat3 in tumor tissues isolated from vehicle and BA-treated (10 mg/kg/day) mice. The treatment with BA markedly reduced MMP-2, MMP-9, Ki67 and P-Stat3-positive cells versus vehicle group (20×).