Table 2. Association of rs2294008 with gastritis-gastric cancer sequence.

Cases	Controls	Cases			Controls			T vs C		TT + TC vs CC
		CC	CT	TT	CC	CT	TT	P-valuea	ORb (95% CI)	P-valuec	ORd (95% CI)
Gastric cancere	Hp- controls	201	1,087	1,041	73	275	189	4.5 × 10–6	1.37 (1.20–1.57)	4.2 × 10–4	1.67 (1.25–2.22)
Hp+	Hp- controls	41	120	119	73	275	189	0.15	1.14 (0.92–1.41)	0.68	0.92 (0.61–1.39)
Severe gastritis, Hp+	Mild gastritis, Hp+	13	74	81	27	45	38	1.0 × 10–3	1.93 (1.36–2.76)	9.4 × 10–5	3.88 (1.90–7.92)
Severe gastritis, Hp+	Hp- controls	13	74	81	73	275	189	1.1 × 10–3	1.52 (1.17–1.98)	0.043	1.88 (1.01–3.48)
Gastric cancere	Severe gastritis, Hp+	201	1,087	1,041	13	74	81	0.37	0.90 (0.71–1.15)	0.69	0.89 (0.50–1.59)

Hp+: H. pylori positive, Hp-: H. pylori negative. ^aP values are calculated by two-sided Cochran-Armitage test. ^bORs are calculated by considering the C allele as a reference. ^cP values are calculated by chi-square test. ^dORs were calculated by considering the CC genotype as a reference. ^eData from the previous study (Tanikawa et al. 2012 Nature Genetics) ¹¹.