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. 2017 Dec 16;9(3):3968–3979. doi: 10.18632/oncotarget.23374

Figure 3. STAT3 inhibition radiosensitizes GSCs.

Figure 3

(A) Plating efficiency of GSC lines in control conditions compared with Stattic or WP1066 pretreatment in the absence of irradiation (N.S. not significant, Mann-Whitney test). (B) Clonogenic survival curves of GSCs treated with irradiation alone or in combination with STAT3 inhibitors were assessed using the linear quadratic model. The mean inactivation dose equal to the area under the survival curves was calculated and the cell survival enhancement ratio (ER) was determined as the ratio of the mean inactivation dose under control conditions divided by the mean inactivation dose after inhibitor treatment.A ratio superior to 1 indicates radiosensitization of GSCs. (C) Comparison of cell surviving fractions after inhibitor treatment for each dose of radiation. Histograms represent the mean ± standard error of the mean of 4 independent experiments (*p < 0.05, Multiple comparison t-test).