Table 2. Univariate analysis of clinical characteristics associated with local progression-free survival (LPFS), relapse-free survival (RFS), and overall survival (OS).
LPFS | RFS | OS | ||||||
---|---|---|---|---|---|---|---|---|
Characteristics | No. of patients, n | 3 year (95% CI), % | p-value† | 3 year (95% CI), % | p-value† | 3 year (95% CI), % | p-value† | |
Gender | Male | 60 | 87.8 (78.1–97.5) | 0.273 | 21.9 (6.6–37.2) | 0.896 | 72.6 (59.7–85.5) | 0.694 |
Female | 11 | 100 (100) | 36.4 (8.0–64.8) | 81.8 (59.0–100) | ||||
Age, years | <60 | 22 | 89.5 (79.2–99.8) | 0.879 | 21.8 (4.1–39.5) | 0.387 | 81.8 (65.7–97.9) | 0.589 |
≥60 | 49 | 90.7 (78.4–100) | 28.8 (13.4–44.2) | 71.3 (60.0–85.6) | ||||
Aetiology of LC | HBV | 57 | 87.3 (77.2–97.4) | 0.214 | 24.3 (11.6–37.0) | 0.497 | 71.4 (58.2–84.7) | 0.445 |
Others | 14 | 100 (100) | 38.7 (12.2–65.2) | 85.7 (67.4–100) | ||||
Child–Pugh Classification | A | 68 | 89.6 (81.3–97.9) | 0.665 | 27.5 (15.3–39.7) | 0.051 | 76.4 (65.1–87.7) | 0.034 |
B | 3 | 100 (100) | 0 (–) | 33.3 (0–86.6) | ||||
AFP, ng/mL | <10 | 43 | 88.8 (77.9–99.7) | 0.882 | 33.7 (19.6–48.2) | 0.098 | 84.2 (72.2–96.2) | 0.032 |
≥10 | 28 | 92.1 (82.1–100) | 17.0 (0–34.6) | 60.0 (39.8–80.2) | ||||
Tumour size, cm | <3 | 64 | 88.8 (80.0 -97.7) | 0.426 | 24.6 (11.6–37.6) | 0.413 | 74.6 (62.6–86.6) | 0.697 |
≥3 | 7 | 100 (100) | 42.9 (6.4–79.6) | 71.4 (38.0–100) | ||||
AJCC stage | I–II | 66 | 89.3 (80.8–97.8) | 0.534 | 25.9 (13.2–38.4) | 0.658 | 77.8 (66.7–88.9) | 0.030 |
IIIA | 5 | 100 (100) | 30.0 (0–76.8) | 30.0 (0–76.8) | ||||
BCLC stage | A | 43 | 91.3 (81.5–100) | 0.447 | 24.0 (8.8–39.3) | 0.899 | 82.0 (69.6–94.4) | 0.090 |
B | 28 | 88.6 (76.4–100) | 29.9 (10.9–48.8) | 61.6 (40.3–82.9) | ||||
Pre-Tx to PBT site | No | 16 | 88.9 (68.4–100) | 0.647 | 31.3 (8.6–54.0) | 0.817 | 93.8 (81.9–100) | 0.087 |
Yes | 55 | 90.4 (82.4–98.4) | 25.7 (11.7–39.6) | 68.7 (91.9–82.5) | ||||
Pre-Tx to other site | No | 11 | 90.9 (73.9–100) | 0.930 | 54.6 (25.2–84.0) | 0.073 | 81.8 (59.0–100) | 0.749 |
Yes | 60 | 89.8 (80.9–98.7) | 22.5 (10.5–34.5) | 73.5 (61.2–85.8) | ||||
Tumour response | CR | 66 | 95.5 (89.1–100) | <0.001 | 28.3 (15.8–40.9) | 0.046 | 81.1% (70.6–91.5) | <0.001 |
Non-CR | 5 | 0 (–) | 0 (–) | 0 (–) |
Abbreviations: CI, confidence interval; CR, complete response; all others are the same as in Table 1.
†log-rank test.