Fig 1.
Rate of [3H]-DPA-713 dissociation from TSPO when using platelets isolated from human subjects with C/C, C/T, and T/T rs6971 genotypes. Left Panels: dissociation of [3H]-DPA-713 in the presence of 2 and 12 μM DPA-713 when using (a) C/C, (c) C/T and (e) T/T genotypes. Right Panels: rate of [3H]-DPA-713 dissociation in the presence of excess unlabeled DPA-713 (12 μM) and effect on this rate by PK 11195 (5 μM) and cholesterol (1.2 μM) when using (b) C/C, (d) C/T and (f) T/T genotypes.