. Author manuscript; available in PMC: 2019 Mar 1.

Published in final edited form as: J Neuroimmune Pharmacol. 2017 Sep 5;13(1):1–5. doi: 10.1007/s11481-017-9765-2

Table 1.

Rate constants of dissociation (k_off in min^-1), residence times (RT = 1/k_off in min) and half-lives (t_½ in min) corresponding to kinetic traces shown in Fig 1.

Displacer of [³H]-DPA-713	Dissociation Parameters
	C/C			C/T			T/T
	k_off	RT	t_1/2	k_off	RT	t_1/2	k_off	RT	t_1/2
DPA-713 (12 μM)	0.74	1.35	0.94	0.76	1.28	0.92	0.56^a	1.78	1.24
DPA-713 (12 μM) + PK11195 (5 μM)	0.76	1.31	0.91	0.75	1.33	0.93	1.90^a	0.52	0.36
DPA-713 (12 μM) + Cholesterol (1.2 μM)	0.65	1.53	1.07	0.72	1.38	0.96	1.58^a	0.63	0.43

One phase exponential decay fits for T/T dissociation traces (Fig 1f) exhibit 95% confidence interval that k_off for [³H]-DPA-713 is faster when PK 11195 or cholesterol are present than when [³H]-DPA-713 dissociates in the presence of DPA-713.