Table 2.
Physical, Mental, and Kidney Disease-Specific Health-Related Quality of Life Pre and Postkidney Transplantation by Frailty Status.
| Pre-KT | Post-KT | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| 1-month change | 3-month change | |||||
|
| ||||||
| Nonfrail | Frail | Nonfrail | Frail | Nonfrail | Frail | |
|
| ||||||
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
| Physical HRQOL | 45.55 (8.66) | 39.31 (9.88) | −7.26 (9.29)* | −5.25 (10.03)* | 0.97 (9.48) | 4.06 (8.78)* |
| Mental HRQOL | 53.06 (8.47) | 52.36 (9.60) | 1.59 (9.77)* | 1.47 (9.98) | 1.61 (9.20)* | 1.60 (10.10) |
| Domains | ||||||
| Physical functioning | 77.02 (20.22) | 61.61 (25.59) | −12.46 (22.77)* | −11.94 (28.12)* | 2.35 (19.56) | 7.29 (24.19)* |
| Role limitations due to physical health problems | 55.88 (38.02) | 41.93 (38.41) | −28.66 (45.58)* | −22.36 (46.90)* | 3.28 (48.99) | 13.97 (45.31)* |
| Bodily pain | 79.90 (23.13) | 46.00 (23.11) | −19.57 (30.69)* | −14.60 (30.23)* | 0.19 (26.47) | 4.00 (27.60) |
| General health | 56.67 (20.45) | 43.60 (23.12) | 8.49 (17.71)* | 11.12 (18.98)* | 6.98 (19.22)* | 10.07 (20.11)* |
| Emotional well being | 83.21 (14.44) | 80.79 (15.74) | 2.46 (16.30)* | 3.29 (16.97) | 3.01 (14.45) | 3.56 (15.22) |
| Role limitations due to emotional problems | 84.50 (29.50) | 79.54 (33.17) | 0.00 (37.89) | −3.14 (37.02) | 1.30 (39.77) | 3.33 (37.71) |
| Social functioning | 82.10 (23.43) | 76.83 (24.83) | −15.56 (29.66)* | −12.75 (31.27)* | 2.68 (24.59) | 1.43 (29.14) |
| Energy | 55.92 (22.85) | 45.37 (25.00) | −2.97 (24.60)* | 0.72 (28.57) | 5.81 (24.58)* | 11.36 (26.35)* |
|
| ||||||
| Kidney disease-specific HRQOL | 76.05 (12.53) | 70.23 (14.41) | 3.94 (10.64)* | 4.15 (11.92)* | 7.90 (10.87)* | 11.07 (12.31)* |
| Domains | ||||||
| Symptoms | 83.24 (12.45) | 77.83 (14.89) | 1.94 (11.62)* | 3.31 (13.96)* | 5.74 (11.30)* | 8.05 (13.28)* |
| Effects | 74.88 (17.91) | 68.02 (22.57) | 7.55 (19.80)* | 8.26 (21.61)* | 12.06 (17.59)* | 18.54 (21.08)* |
| Burden | 54.65 (28.41) | 45.91 (29.37) | 11.76 (26.39)* | 13.95 (25.70)* | 19.99 (27.61)* | 22.31 (30.37)* |
| Cognitive function | 86.26 (15.57) | 80.77 (19.88) | 2.35 (14.57) | 2.69 (17.43) | 5.10 (14.03)* | 6.81 (13.68)* |
| Social interaction | 83.92 (15.47) | 79.83 (16.78) | −2.85 (16.56)* | −0.44 (15.41) | 0.44 (14.48) | 3.29 (18.84) |
| Sleep | 64.58 (20.23) | 59.46 (22.80) | 1.76 (24.55) | −0.13 (22.38) | 6.64 (20.44)* | 11.34 (21.53)* |
| Social support | 84.69 (20.15) | 79.71 (22.03) | 4.47 (23.17)* | 0.68 (23.92) | 5.29 (22.17)* | 6.72 (22.10) |
(Key: HRQOL= Health-Related Quality of Life, KT= Kidney Transplantation). Unadjusted mean HRQOL scores were measured pre-KT and compared to scores at 1-month and 3-months post-KT.
*
indicates statistical significant changes in scores compared to KT. All measures of HRQOL made using the Kidney Disease Quality of Life instrument short form (KDQOL-SF) (35).