Table 3. Subgroup analysis of mean changes in systolic blood pressure as assessed by 24-h ambulatory blood pressure monitoring.

Subgroup		SBP (as assessed by 24-h ABPM)
		No. of studies	Mean net change	95% CI	p; I2 (%)
AHI	≥ 30	4	−3.07	−5.50 to −0.65	p = 0.01; I2 = 22%
	> 30	2	−9.58	−11.70 to −7.46	p < 0.00001; I2 = 0%
Baseline SBP/DBP, mmHg	> 145/85	2	−9.58	−11.70 to −7.46	p < 0.00001; I2 = 0%
	< 145/85	4	−3.07	−5.50 to −0.65	p = 0.01; I2 = 22%
BMI, kg/m2	≥ 32	3	−6.81	−8.55 to −5.08	p < 0.00001; I2 = 89%
	< 32	3	−6.47	−10.53 to −2.42	p = 0.002; I2 = 0%
CPAP compliance, h	> 5	4	−7.47	−9.18 to −5.76	p < 0.00001; I2 = 70%
	≤ 5	1	1.20	−4.12 to 6.52	p = 0.66; I2 = 0%
Treatment duration, months	> 3	2	−8.03	−10.06 to −6.00	p < 0.00001; I2 = 93%
	≤ 3	4	−4.71	−7.29 to −2.12	p = 0.0004; I2 = 0%
ESS score	≥ 10	3	−5.89	−13.33 to 1.55	p = 0.12; I2 = 85%
	< 10	3	−4.19	−6.92 to −1.47	p = 0.003; I2 = 0%
Location	Europe	3	−4.19	-6.92 to −1.47	p = 0.003; I2 = 0%
	South America	3	−8.10	−10.07 to −6.13	p < 0.00001; I2 = 85%
Study sample size	≥ 25	3	−0.20	−0.41 to −0.01	p = 0.06; I2 = 36%
	< 25	3	−0.96	−1.36 to −0.57	p < 0.00001; I2 = 88%

SBP: systolic blood pressure; DBP: diastolic blood pressure; ABPM: ambulatory blood pressure monitoring; AHI: apnea-hypopnea index; BMI: body mass index; CPAP: continuous positive airway pressure; and ESS: Epworth Sleepiness Scale.