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| Outcome | Patient-centered | Composite | Surrogate |
|---|---|---|---|
| Asthma | Asthma control (questionnaire) | Hospitalization or a > 20% decline in asthma control | FEV1, peak flow, eosinophils |
| PAH | 2-year survival | Lung transplantation or death | 6MWD, PASP |
| ARDS | Hospital survival | Time to extubation or tracheotomy | PaO2/FiO2 ratio, ventilator-free days |
PAH: pulmonary arterial hypertension; 6MWD: six-minute walk distance; and PASP: pulmonary artery systolic pressure.
