Table 1.

Linear range and limit of detection of the proposed method in comparison with some previous methods for analysis of morphine and ibuprofen.

Compound	Method	Linear range (μg/mL)	LOD (μg/mL)	Reference
Morphine	RP-HPLC	0.15–2	0.05	[41]
	LC-MS-MS	0.002–2	0.001	[42]
	Direct aqueous derivatization	0.008–5.0	0.002	[43]
	GC-MS	0.02–20	0.003	[44]
	Spectrophotometry	0.025–2	0.002	[45]
Ibuprofen	Derivatives of the ratio spectra method	2–32	0.53	[46]
	HPLC	6.1–200	1.7	[47]
	Spectrophotometry	0.28–6.9(IBU)	0.03(IBU)-	This work
		1.33–33.29 (MOR)	0.15(MOR)

RP-HPLC: Reverse phase-high performance liquid chromatography; LC-MS-MS: Liquid chromatography-tandem mass spectrometry; GC-MS: Gas chromatography-mass spectrometry; HPLC: High performance liquid chromatography