Figure 3.

A moderate portion of layer II EC neurons project directly to hippocampal CA1. A, Rabies-labeled neurons in the medial entorhinal cortex (MEC) contain both layer III pyramidal cells and layer II cells. The white arrow points to a layer II cell. The scale bar (100 μm) applies to both A and B. B, Rabies-labeled neurons in the lateral entorhinal cortex (LEC) also contain layer III pyramidal cells and layer II cells. C, The example rabies-labeled MEC layer II cells are calbindin (CB) immunopositive, but reelin negative. D, The example rabies-labeled MEC layer II cell is reelin immunopositive, but CB negative. Scale bar in C = 100 µm, applies to both C and D.