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. 2018 Jan 26;9:66. doi: 10.3389/fmicb.2018.00066

Figure 4.

Figure 4

Comparison between blaOXA-58-containing genetic structures carried by Acinetobacter plasmids. Nine blaOXA-58 containing-adaptive modules carried by Acinetobacter plasmids (indicated at the right) and the corresponding genetic contexts in which they are inserted (a–i) are depicted, with that found in pAb242_25 (this work) shown at the top. The gray-shaded background interconnecting the different structures highlights the homologous regions (nucleotide sequences ≥ 95% identity). Inverted regions between a given pair of structures are depicted with gray cross sectors. The different CDS and corresponding orientations are denoted, with truncated or interrupted genes indicated by gray boxes with white arrowheads inside indicating their original orientations. The blaOXA-58 CHDL and aphA6 aminoglycosides resistance genes are labeled in black. The different IS interrupting the ISAba3 element located upstream of blaOXA-58 are indicated by the designations adopted in the corresponding references. In (a,b), the regions encompassing the composite transposon TnaphA6, their different directions and insertion sites within the lysE gene, and the remnants of this gene (ΔlysE) in each case are indicated. The inferred XerC/D-like sites are shown as in Figure 2. In (b–i), the sites noted previously by other authors (see references below) are indicated by asterisks below the structures. In the case of pMAD (c) the two original XerC/D sites located at the borders of the module are indicated by their original designations Re27-1 and Re27-2, respectively. The slash (/) symbols at the borders of a given structure indicate that further sequence data was provided in databases beyond these positions; otherwise the structure was interrupted at the point where no further sequence information was available. Further details on the XerC/D sites, plasmids, and the Acinetobacter species from which they were isolated or characterized are provided in Tables S3, S7 and in references (Poirel and Nordmann, 2006; Zarrilli et al., 2008; D'Andrea et al., 2009; Merino et al., 2010; Grosso et al., 2012; Fu et al., 2014; Blackwell and Hall, 2017).