Table 1.

Enriched biological processes of predicted targets for matrine.

Biological process class	Gene ontology term	Reference
Neuroprotective or neurotoxic effect	Synaptic transmission	Yin and Zhu, 2005
	Neurological system process	Lu et al., 2014
	Glutamate signaling pathway	Zhang and Song, 2014
Analgesic effect	Sensory perception of pain	Wang et al., 2013
Memory enhancement and sleep improvement	Learning or memory	Cui et al., 2017
	Rhythmic process	Liu and Li, 2012
Lipid and energy metabolism	Fatty acid metabolic process	Zeng et al., 2015
	ATP metabolic process	NA
Pharmacological action on ion channel	Ion transport	Wei et al., 2013
Anti-inflammatory and immunological regulation	Inflammatory response	Zhang B. et al., 2011
	Lymphocyte activation	Zhao et al., 2011
Cardiovascular effect	Regulation of catecholamine secretion	Wang and Liu, 2012
	Tissue remodeling	Zhang et al., 2006
Anti-viral effect	Viral reproduction	Li et al., 2005
Vesicle formation and endocytosis	Membrane invagination	NA
	Endocytosis	NA
Anti-tumor effect	Regulation of cell proliferation	Liang et al., 2012
	Biological adhesion	Zhang et al., 2013
	Angiogenesis	Liu et al., 2014
	Cell migration	Wang et al., 2017