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. 2018 Jan 26;9:9. doi: 10.3389/fneur.2018.00009

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Copyright © 2018 Bishop, Ricotti, Sinclair, Evans, Butler, Morrow, Hanna, Matthews, Yousry, Muntoni, Thornton, Newbould and Janiczek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plots showing how a subset of the Magnetic Resonance Imaging-derived summary measures (min CSA, top row; min TDM, second row; max TDM, third row) and spirometry metrics (FVC, fourth row; %Pred, fifth row; and MEP, last row) relate to the disease progression surrogates of age (left plots) and months non-ambulatory (middle plots), as well as follow-up visit (right plots). Min CSA, minimum lung cross-sectional area; min/max TDM, minimum/maximum total distance of motion (TDM) of the diaphragm; FVC, forced vital capacity; %Pred, FVC as a percentage of predicted normal values; MEP, maximal expiratory pressure.