. 2018 Jan 26;9:32. doi: 10.3389/fphar.2018.00032

Table 2.

Original researches reports which stressed the effectiveness of anticancer drugs in the presence of H₂S.

References	Effectiveness of anticancer drugs
Chegaev et al., 2016	Doxorubicin has a more potent cytotoxicity on both doxorubicin-sensitive osteosarcoma cells U-2OS and doxorubicin-resistant osteosarcoma cells U-2OS/DX30, U-2OS/DX100 and U-2OS/DX580 in the presence of H₂S than that in the absence of H₂S. The inhibitory effect of H₂S on the P-glycoprotein in the doxorubicin-resistant osteosarcoma cells, resulting in the reduced efflux of doxorubicin and increased intracellular accumulation of DOXO, might be involved in the enhanced effectiveness of doxorubicin.
Tesei et al., 2012	1. Valproic acid induced an increase in cytotoxicity and mitochondria-dependent cell apoptosis but a decrease in invasive activity in cell lines of the non-small cell lung cancer (NSCLC) in the presence of H₂S. 2. Cisplatin caused an increased cytotoxicity on the NSCLC cells when it was administrated in the presence of an H₂S-releasing valproate derivative ACS2. 3. The cytotoxic effect of doxorubicin on the NSCLC cells was enhanced by the combined treatment with ACS2.

References

Effectiveness of anticancer drugs

Chegaev et al., 2016

Doxorubicin has a more potent cytotoxicity on both doxorubicin-sensitive osteosarcoma cells U-2OS and doxorubicin-resistant osteosarcoma cells U-2OS/DX30, U-2OS/DX100 and U-2OS/DX580 in the presence of H₂S than that in the absence of H₂S. The inhibitory effect of H₂S on the P-glycoprotein in the doxorubicin-resistant osteosarcoma cells, resulting in the reduced efflux of doxorubicin and increased intracellular accumulation of DOXO, might be involved in the enhanced effectiveness of doxorubicin.

Tesei et al., 2012

1. Valproic acid induced an increase in cytotoxicity and mitochondria-dependent cell apoptosis but a decrease in invasive activity in cell lines of the non-small cell lung cancer (NSCLC) in the presence of H₂S.
2. Cisplatin caused an increased cytotoxicity on the NSCLC cells when it was administrated in the presence of an H₂S-releasing valproate derivative ACS2.
3. The cytotoxic effect of doxorubicin on the NSCLC cells was enhanced by the combined treatment with ACS2.