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. 2018 Jan 26;9:19. doi: 10.3389/fmicb.2018.00019

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Copyright © 2018 Hottmann, Mayer, Tomek, Friedrich, Calvert, Titz, Schäffer and Mayer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified scheme of the MurNAc and PGN metabolic pathways in T. forsythia. Proteins required for MurNAc uptake and utilization, encoded by the Tf_murTKQ operon of T. forsythia, are shown in red. Some generally essential and well-conserved bacterial PGN biosynthetic enzymes are missing in T. forsythia (colored in blue, crossed out). Black arrows indicate metabolic enzymes (solid) and pathways (dashed) that are apparently present in T. forsythia. Question marks indicate enzymes or pathways that are suggested to be present in T. forsythia based on results obtained in the frame of this study.